Vitex negundo (Lagundi) contains antioxidant phenolic compounds and flavonoids such as casticin, chrysoplenol D, luteolin, iso-orientin, and luteolin-7-0-glucoside. Other compounds such as epicatechin, quercetin, catechin, myricetin, tocopherol, β-carotene and lycopene were also found to be present in lagundi leaf extracts. Chrysoplenol D was identified as the bioactive substance having anti-histaminergic and muscle relaxant properties particularly useful for cough and asthma.  Lagundi is also used for the treatment colds, fever, flu, chronic bronchitis, pharyngitis, rheumatism, dyspepsia, boils, diarrhea, and certain skin or digestive complaints. Primarily it is recognized as herbal medicine for respiratory problems.

Five-leaved chaste tree/Lagundi

Other Names: 
Chinese chaste tree, Five-leaved chaste tree, Horseshoe vitex
Other Traditional Medicinal Uses: 
    • Expectorant/Cough Remedy
    • Sore throat relief
    • Anti-asthma/Bronchodilator
    • Antioxidant
    • Anti-inflammatory
    • Diuretic
    • Antinociceptive/Analgesic
    • Anti-allergy
    • Antihyperglycemic
    • Antimicrobial
    • Anthelmintic /Antiparasitic
    • Promotes wound healing
    • Hepatoprotective
    • Improves digestion
    • Carminative
    • Relieves anxiety
    • Promotes relaxation
    • Insecticidal
    • Reduces risk of cancer
References: 
  • http://www.nmpc.com.ph/website/services/show/id/7 https://www.ncbi.nlm.nih.gov/pubmed/25641408
  • https://www.researchgate.net/profile/A_S_Vishwanathan/publication/267716089_A_Review_on_Vitex_negundo_L_-
    _A_Medicinally_Important_Plant/links/5602ceb208aeaf867fb80f60/A-Review-on-Vitex-negundo-L-A-Medicinally-Important-Plant.pdf
  • http://www.academicjournals.org/journal/AJBR/article-abstract/743A94611519
  • http://www.academicjournals.org/journal/JMPR/article-abstract/6A593BF23500
  • http://curriculum.nismed.upd.edu.ph/wp-content/uploads/2012/06/Table-of-the-10-DOH-approved-medicinal-plants.pdf
  • http://scinet.dost.gov.ph/union/SearchHoldings/bsub_view1.php?&sub=Chrysoplenol%20D
  • http://scinet.dost.gov.ph/union/ShowSearchResult.php
    ?s=2&f=&p=&x=&page=&sid=1&id=Phytochemical+studies+on+the+leaves+of+%3Cem%3EVitex+negundo%3C%2Fem%3E+L.+%28lagundi%29&Mtype=ANALYTICS
  • http://www.philippineherbalmedicine.org/lagundi.htm
  • http://www.philippineherbalmedicine.org/doh_herbs.htm http://vrh.doh.gov.ph/index.php/en/health-guide#traditional-alternative-medicine http://www.medicalhealthguide.com/articles/lagundi.htm http://www.sciencedirect.com/science/article/pii/S0367326X08001305
  • http://www.sciencedirect.com/science/article/pii/S0378874103001594 http://www.ijpsonline.com/articles/essential-oil-composition-and-antibacterial-studies-of-vitex-negundo-linn-extracts.html http://www.ijpp.com/IJPP%20archives/2005_49_2/163-170.pdf
  • https://www.hindawi.com/journals/ecam/2013/739850/abs/
  • http://search.proquest.com/openview/8781447ea2f5550569551c84a26be109/1?pq-origsite=gscholar&cbl=226497
  • https://www.cabdirect.org/cabdirect/abstract/20103346228 https://link.springer.com/article/10.1007%2FBF02857823?LI=true
  • http://www.sciencedirect.com/science/article/pii/S0960894X06011127 http://nopr.niscair.res.in/handle/123456789/18976
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  • http://pubs.acs.org/doi/abs/10.1021/np50080a002?journalCode=jnprdf http://nopr.niscair.res.in/handle/123456789/8085
  • http://www.thaiscience.info/journals/Article/CMJS/10905473.pdf
  • http://www.philstar.com/health-and-family/2012/07/17/828459/medicinal-wonders-lagundi